Eisenberg made his Broadway debut as an understudy in a 1996 revival of Summer and Smoke. He made his screen debut on the 1999 television series Get Real, which was canceled in 2000. After appearing in the made-for-television film Lightning: Fire from the Sky, he starred in the independent film, Roger Dodger (for which he won an award at the San Diego film festival), and in the inspirational film The Emperor's Club, both of which were released in 2002 to generally positive reviews.

In 2005, Eisenberg appeared in Cursed, a horror film directed by Wes Craven, and The Squid and the Whale, a well-reviewed independent drama also starring Laura Linney and Jeff Daniels. His stage credits include Scarcity at the Atlantic Theater Company (2007) and a workshop production of Lyle Kessler's Orphans in Los Angeles (2006). In 2007, he starred opposite Richard Gere and Terrence Howard in The Hunting Party, a comic thriller in which he plays a young journalist in Bosnia.

In 2009, Eisenberg played the lead role in Adventureland, a comedy directed by Greg Mottola and filmed in Kennywood Park near Pittsburgh, Pennsylvania. Filming ended in October 2007 and the movie premiered at the Sundance Film Festival in 2009. Fellow cast members included Kristen Stewart and Bill Hader. In November 2007, Eisenberg was cast in an indie comic-drama, Holy Rollers. He plays a young Hasidic Jew who gets lured into becoming an ecstasy dealer. Filming was scheduled to begin in New York in 2008.

He plans to write for stage and screen. (Via Wikipedia)